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City Austin / Cambridge / Estarreja / / Company Bernstein / Goff S. P. / / Country United States / Portugal / United Kingdom / / / Event Product Issues / / Facility Howard Hughes Medical Institute / University of Utah School / / IndustryTerm random site / endogenous homologous recombination machinery / endogenous recombination machinery / machinery / cellular machinery / desired targeted homologous recombination products / target site / drug-selection protocols / gene product / selection protocol / host site / homologous recombination machinery / enzymatic machinery / / MedicalCondition embryonal carcinoma / purified herpes / Alveolar rhabdomyosarcomas / herpes / alveolar rhabdomyosarcoma cell / mouse tumours / cancers / linked herpes virus thymidine kinase / embryo-derived teratocarcinoma cell lines / Moloney sarcoma virus / / Organization University of Utah School of Medicine / National Institute of Health / Howard Hughes Medical Institute / Department of Human Genetics / Fgf and Wnt / / Person Mario R. Capecchi / Oliver Smithies / Martin Evan / Plotkin / Frank Ruddle / Mansour / Barbosa / Martin Evans / / Position investigator / D. J. / Bishop / reporter / / Product thioguanine / neomycin resistance / neor gene / neor genes / genes / / Technology selection protocol / directed mutagenesis / stem cells / electroporation / gene expression / recombination system / gene targeting / drug-selection protocols / good protocol / recombination / / URL http / SocialTag 
PERSPECTIVES in cultured mammalian cells. The second was how to transfer this genetic modification to the mouse germline. Oliver Smithies’ laboratory and mine worked independently on solutions to the first problem. Mar