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Medicinal chemistry / Pharmacology / Chemical bonding / Aldose reductase / Sorbinil / Quantitative structure–activity relationship / Ligand / Sorbitol dehydrogenase / Tolrestat / Chemistry / EC 1.1.1 / Organofluorides


doi:[removed]j.jmgm[removed]
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Document Date: 2010-12-19 08:35:07

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City

Chichester / New York / Weinheim / HKSAR / San Diego / Physiologically / /

Company

Neural Networks / Cl / Alan R. Liss Inc. / Gaussian Inc. / Ligand / initio HF / CN / Elsevier Inc. / Oxford University Press / John Wiley and Sons Ltd. / Brookhaven Protein Data Bank / VCH Verlag GmbH / Shimizu / J. Pharm / Accelrys Inc. / /

Country

United Kingdom / China / /

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Facility

University of Hong Kong / Prentice Hall / The University of Hong Kong / /

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IndustryTerm

active site / hydrogen donor site / free energy / sugar substrate site / interaction energy / finance / aldose reductase active site / large repulsion energy / energy / carrier proteins / energy function / chemical reactions / aldose reductase inhibitor site / empirical binding free energy function / functional / energy perturbation method / point energy correction / estimated free binding energy / functional groups / methyl / energy calculation methods / chemical / anion binding site / chemical structure / hydrophobic active site / 3D-database search / macromolecular energy / /

MedicalCondition

Vascular Disease / Introduction Insulin-dependent diabetes / metabolic disorders / certain diabetic complications / diabetic complications / Hyperglycemia / diabetes / diabetes mellitus / retinopathy and cardiovascular disease / deficiency / /

NaturalFeature

Upper Saddle River / /

Organization

Department of Chemistry / China Department of Anatomy / Comprehensive Foundation / University of Hong Kong / Oxford University / Prentice Hall / /

Person

Nat / Raymond Ming-Wah Chau / Pauline Chiu / R.J. Williams / D.E. Patterson / Brooks III / M.P. Giovannoni / V / Angel de la Fuente / B.D. Olafson / Stephen Chung / /

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Position

D.J. / Corresponding author / Professor / head of spirohydantoins / /

Product

acetic acid / sorbitol / /

ProvinceOrState

New York / California / Arkansas / /

PublishedMedium

Molecular and Cellular Biology / /

Technology

Molecular modeling / X-ray / Computational Chemistry / drug discovery / neural network / simulation / /

URL

www.elsevier.com/locate/JMGM / /

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