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Immune system / DNA / Molecular biology / Allopurinol / Stevens–Johnson syndrome / HLA-B / Human leukocyte antigen / HLA-A / Genome-wide association study / Genetics / Biology / Genes


A whole-genome association study of major determinants for allopurinol-related Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese patients
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Document Date: 2013-01-24 00:59:03

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City

Patients / Tokyo / San Diego / /

Company

Migueles SA / Wout AB / Takeda Pharmaceutical / Macmillan Publishers Limited. / BT / Haneline SA / Ge / Taisho Pharmaceutical / Wilson AG / Daiichi Sankyo / HP / Otsuka Pharmaceutical / Donaldson / Astellas Pharma / Mitsubishi Tanabe Pharma / /

Country

Japan / United States / /

Currency

pence / /

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Facility

Medical Research Institute / National Epilepsy Center / Institute of Epilepsy / Nagoya City University / National Institute of Health Sciences / Kyoto Prefectural University of Medicine / Dental University / National Oomuta Hospital / National Institute of Health Sciences.10 In / /

IndustryTerm

research / /

MedicalCondition

SCAR / renal dysfunction neutropenia liver dysfunction renal dysfunction / allopurinol-related SCARs / drug hypersensitivity / liver dysfunction GI tract disturbance liver dysfunction / JE / Possible psoriasis / Stevens Johnson syndrome / rheumatoid arthritis / skin cancer / immune system disorder / neutropenia liver dysfunction / toxic epidermal necrolysis / Stevens-Johnson syndrome / extensive erythema / Gout / hypersensitivity syndrome / StevensJohnson syndrome / respiratory involvement liver dysfunction / renal dysfunction liver dysfunction liver dysfunction renal dysfunction / erythema multiforme / renal dysfunction renal dysfunction / Johnson syndrome / psoriasis / hypersensitivity / MS / high fever / renal dysfunction / psoriatic arthritis / sporadic cancer / blisters / mucocutaneous disorders / allopurinol-related SCAR / drug-induced skin blistering disorders / disease / SCARs / complex diseases / liver dysfunction renal dysfunction neutropenia liver dysfunction / enanthema and high fever / exanthema / AIDS / allopurinol-induced SCAR / infection / drug-induced liver injury / renal dysfunction liver dysfunction renal dysfunction neutropenia liver dysfunction / /

Organization

National Institute of Health / National Oomuta Hospital / Medical Research Institute / Department of Dermatology / Tokyo Medical and Dental University / Tokyo / Japan Pharmacogenomics Data Science Consortium / Japanese Central Bone Marrow Data Center / National Epilepsy Center / Department of Neurology / Department of Ophthalmology / Pharmacogenomics Journal Whole-genome association / Institute of Health Sciences / Schuitemaker H. Association of HLA-C / Department of Medicinal Safety Science / City University Graduate School / HCP5 / 5Shizuoka Institute of Epilepsy and Neurological Disorders / Kyoto Prefectural University of Medicine / Kyoto / Strong / Neuro-Muscular Center / Fujita Health University School of Medicine / Association of SEEK1 / Ministry of Health / City University / /

Person

Stevens Johnson / Arch Dermatol / Ichiro Nakaoka / Ann Rheum / /

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Position

Bettinotti MP / General / Workman / Major / Fisher / Representative / /

Product

acetaminophen / pseudo / valsartan / cefazolin / olmesartan medoxomil / promethazine / allopurinol / clarithromycin / losartan / levofloxacin / Sodium polystyrene sulfonate / lansoprazole / abacavir / spironolactone / Furosemide / /

ProvinceOrState

Oregon / /

PublishedMedium

PLoS One / The Pharmacogenomics Journal / /

RadioStation

Marincola FM / Hecht FM / /

Technology

Genomics / Bioinformatics / genotyping / single nucleotide polymorphism / DNA Chip / SNP / genotype / /

URL

www.nature.com/tpj / /

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