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City Noguchi / Key / Paris / Onakoya / / Company Gould / SCA / Methods Laboratory / Robbins AB / LG / Eaton / Bunn HF / HP / / Country France / / / Facility Tenon Hospital / / IndustryTerm Online Supplementary Table S1 / Cerebral imaging / online version / energy / energy metabolism / Hemoglobin SC disease Treatment / / MedicalCondition arterial thrombosis / strokes / HIV / viral infection / tricuspid regurgitation / HBV / separate disease / hemoglobin SC disease / both HbSC disease / myocardial necrosis / retinal detachment / pulmonary arterial hypertension / measurable pulmonary regurgitation velocity / sickle cell anemia / chronic renal failure / Painful vaso-occlusive crisis Acute chest syndrome Priapism / Peak tricuspid regurgitation / extensive medullary necrosis / thrombotic thrombocytopenic purpura / inherited diseases / pulmonary acceleration time / hepatitis B / multiorgan failure syndrome / retinopathy / sensorineural otological disorders / spontaneous abortions / albuminuria / blood hypertension / chronic kidney disease / reversible hypotension / vestibular syndrome / thrombotic accident Infections / chronic organic clinical characteristics / renal involvement Glomerular hyperfiltration Microalbuminuria Macroalbuminuria Renal insufficiency / chronic organic complications / patient experienced stroke / retinopathy / otological disorders / transient ischemic stroke / also called sickle cell anemia / hemoglobinopathy / chronic / ESRD / stroke / HCV / leg ulcers / viscosity-associated otological and ophthalmological disorders / fever / HbSC disease / Relative systemic hypertension / common chronic organ complications / HIV-associated nephropathy / France ABSTRACT Background Hemoglobin SC disease / coronary thrombus / diseases / Early glomerular dysfunction / sickle cell hemoglobinopathies / high blood pressure / renal failure / homozygous sickle cell disease / disorders / retinopathy and sensorineural otological disorders / Sensorineural otological disorders / progressive renal failure / osteonecrosis / frequent hemoglobinopathies / TB / gallbladder disease / marrow embolism / acute chest syndrome / Haymann J-P. Hemoglobin sickle cell disease / nephropathy / pulmonary arterial hypertention / retinopathy / avascular bone necrosis / severe infectious complications / benign disease / hepatitis C / vitreous hemorrhage / low blood pressure / otological disorders / adult sickle cell anemia / main chronic disorders / massive pulmonary embolism / hemolytic and non-hemolytic related endothelial dysfunction / permanent hearing loss / chronic kidney diseases / hearing loss / cell anemia / frequent hemoglobinopathy / Hearing impairment / Castro O. Overt iron deficiency / nephropathy and avascular necrosis / HIV infection / otologic disorders / priapism / Iron deficiency / acute multiorgan failure syndrome / hypertension / disease / cerebral infarction / frequent chronic organic feature / homozygous SS disease / frequent chronic complication / venous thrombosis / Hemoglobin SC disease N / vertigo / Hemoglobin SC disease Introduction Hemoglobin sickle cell disease / Osteomyelitis Salmonella Typhi Tuberculosis Pneumococcal disease Chronic / pulmonary hypertension / C disease / pain / renal insufficiency / myocardial infarction / diabetes mellitus / suspected pulmonary arterial hypertension / sickle cell disease / pulmonary thrombo-embolism / Hb SC Disease / sickle cell trait / Chronic organ dysfunctions / cough / Thrombosis / Nathan S. Hemoglobin S-C disease / anemia / pulmonary regurgitation / / MedicalTreatment bed rest / catheterization / heart catheterization / / NaturalFeature Gladwin MT / / Organization Canadian Society of Echocardiography / European Association of Echocardiography / European Society of Cardiology / ND ND / American Society of Echocardiography / Tenon Hospital / Ferrata Storti Foundation / Republicans / / Person François Lionnet / Marie Curie Paris / Nathan S. Hemoglobin / Arch Pediatr / Arch Intern / / / Position Hb / experienced physician / femoral head / / Product hydroxyurea / / ProvinceOrState Nova Scotia / / RadioStation Noone AM / / Technology X-ray / genotype / AV / polymerization / ultrasound / laser / / URL www.haematologica.org / www.icmje.org / / SocialTag