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Anatomy / Cytokines / Alopecia areata / CD8+ cell / T helper cell / Interferon-gamma / Interleukin / CD8 / CD25 / Biology / Immune system / T cells


letters Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition Luzhou Xing1,7, Zhenpeng Dai2,7, Ali Jabbari2,7, Jane E Cerise2,3, Claire A Higgins2, Weijuan Gong2, Annemieke de Jong2, Siv
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Document Date: 2014-08-17 18:33:37

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City

Helsinki / Valencia / Palo Alto / San Carlos / San Diego / /

Company

Bezman N.A. / Durect Corporation / IgG / AA / Sigma-Aldrich / Affymetrix / Qiagen Inc. / Hewlett-Packard Company / Jackson Laboratories / NuGEN Technologies Inc. / /

Country

United States / Columbia / /

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Event

FDA Phase / Product Issues / /

Facility

Bar Harbor / Columbia University Medical Center / Columbia University / Scale bar / Rockefeller University Genomics Core Facility / University Skin Disease Research Center / /

IndustryTerm

online version / cancer therapy / treatment of myelofibrosis24 / 25 / a disease / gene chips / treatment of psoriasis / advance online publication / ONLINE METHODS Mice / /

MarketIndex

ALADIN / /

MedicalCondition

celiac disease / Alopecia / T cell inflammatory pathways / multiple sclerosis / myeloproliferative neoplasms / psoriasis / patchy alopecia areata / cutaneous lymphadenopathy / severe disease / Alopecia areata / Severe Alopecia Areata / myelofibrosis / autoimmune diseases / R. Alopecia areata / cancer / disease / CD4+/CD25+cells blockade disease / established disease / R.S. Alopecia areata / systemic alopecia areata / autoimmune disease / dermal inflammatory signature / SCID / infection / inflammation / human disease / /

MedicalTreatment

skin grafts / cancer therapy / /

Organization

Columbia University Skin Disease Research Center / Institutional Review Board / Genome-wide association / Department of Dermatology / Institutional Animal Care and Use Committee / Clinical Trials Unit / Love Foundation / National Alopecia Areata Foundation / Columbia University / New York / Dermatology Foundation / Columbia University Medical Center / US Food and Drug Administration / Rockefeller University / /

Person

Nat / M. Duvic / V / L.E. Jr / Ingber / /

Position

D.E. Gene Expression Dynamics Inspector / AUTHOR / King / Fisher / representative / A.d.J. / /

Product

C3H/HeJ / Sigma / IL-2 / IL-15Rb / JAK1 / mice / JAK3 / JAK2 / /

ProvinceOrState

New York / Nova Scotia / California / /

PublishedMedium

PLoS ONE / /

Technology

Genomics / Bioinformatics / antibodies / 2.0 gene chips / 430 2.0 gene chips / DNA Chip / gene expression / treating cancer / /

URL

http /

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