| Document Date: 2011-11-28 13:01:58
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Company Ligand / / Event Product Issues / / Facility MGC29565 TRAIL / TRAILR3 TRAIL / TRAILR4 TRAIL / terminal Death Domain Locuslink ID / KILLER/DR5 TRAIL / / IndustryTerm Online Mendelian Inheritance / search window / / MedicalCondition sweat gland formation Ectodermal Dysplasia / tumor / RANK osteoporosis / TNFRSF23 tumor necrosis / TNFRSF1B tumor necrosis / endotoxic shock / TNFRSF12L tumor necrosis / TNFRSF22 tumor necrosis / arthritis / Genetic Diseases / hyper-IgM syndrome / T cells Autoimmune Lymphoproliferative Syndrome / Systemic Autoimmunity Autoimmune Lymphoproliferative Syndrome / Th2 development Increased Th2 responses Th2 deficiency / septic shock / germinal center formation X-linked hyper-IGM syndrome / Lymphadenopathy / Mediates TNF-induced inflammation / tumor cell killing defective NK-mediated tumor / deficiency Human Genetic Diseases / inflammation / inflammation Wasting syndrome / TNFSF2 tumor necrosis factor / activation Osteopetrosis / osteoclast deficiency / TNFRSF1A tumor necrosis / syndrome / TNF-induced arthritis / asthma / / NaturalFeature ALPS / / Organization Germinal Center / / Position TNFRSF14 Herpes Virus Entry Mediator / Mediator / / Product CD8 / Ig / Ig class switching / NK-mediated tumor eradication / sensory neuron innervation / germinal center formation X-linked hyper-IGM syndrome / GC formation / apoptosis / CD4 / resistance / / ProgrammingLanguage DC / / Technology alpha / apoptosis / / URL http /
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TABLE 1: TNF superfamily Ligands LocusLink ID Symbol Common name Position Aliases Binds to Receptor(s) OMIM ID Key Functions Phenotype associated with overexpression Phenotype associated with deficiency Human Genetic D