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PD-L1 / T cells / Immunology / Hypoxia-inducible factors / T helper cell / Monocyte / Tumor hypoxia / Macrophage / Cytokine / Biology / Cell biology / PD-1


Brief Definitive Report PD-L1 is a novel direct target of HIF-1, and its blockade under hypoxia enhanced MDSC-mediated T cell activation Muhammad Zaeem Noman,1 Giacomo Desantis,2 Bassam Janji,3
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City

Verona / IFN / MDSC / Padua / Villejuif / Durham / /

Company

B16-F10 LLC / The Rockefeller University Press / IgG / MDSCs / Life Technologies / K.R. Stenmark S.P. / B16 (D) LLC / M.M. Hickey S.A. / Creative Commons / /

Country

Italy / France / United States / /

Currency

USD / /

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Event

FDA Phase / /

Facility

Verona University / Gustave Roussy Cancer Institute / /

IndustryTerm

heterogeneous / tumor site / /

MedicalCondition

ovarian cancer / inflammatory hypoxia / metastasis / CT26 colon carcinoma / human tumor / mouse tumor / solid tumors / tumor inflammation / melanoma / hypoxic tumor / Each tumor / A549 lung cancer / combinational therapy targeting tumor / ovarian carcinoma / dissociation / tumor / different tumor / advanced cancers / cancer / tumors / disease / sur le Cancer / decreased tumor / anti tumor / durable tumor / 4T1 mammary tumors / melanomas / advanced cancer / mechanical dissociation / oncogene-driven melanomas / 4T1 mammary carcinoma / le Cancer / renal anemia / murine mammary carcinoma 4T1 / tumours / /

MedicalTreatment

antibiotics / immunotherapy / immunosuppression / /

NaturalFeature

Charles River / /

Organization

Verona University / Verona / Verona University / Animal Experimentation and Ethics Committee / Luxembourg 4Functional Genomic Unit / Rockefeller University / Department of Oncology / Public Research Center for Health / Salem Chouaib1 Institut National / European Union / Gustave Roussy Cancer Institute / Institut de Cancérologie / French Ministry of Research / /

Person

Gustave Roussy / J. Van Pelt / Nat / Salem Chouaib / D. Redelman / Muhammad Zaeem Noman / D.F. McDermott / Lewis Lung Carcinoma / S. Ring / V / K.W. Hunter Jr. / /

Position

RT / Dual-Luciferase Reporter / reporter / /

Product

IL-10 / ammonium chloride / Gr1 / /

ProvinceOrState

Prince Edward Island / South Dakota / /

PublishedMedium

la Recherche / /

Technology

alpha / siRNA / antibodies / directed mutagenesis / apoptosis / Cell Signaling Technology / electroporation / gene expression / 5 789 ChIP / http / /

URL

http /

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