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Cellular processes / Mammalian target of rapamycin / Cell growth / DNA repair / Sirolimus / Schizosaccharomyces pombe / Wee1 / Magnesium in biology / Homologous recombination / Biology / Cell biology / Cell cycle


Molecular Cell Short Article TORC2 Signaling Pathway Guarantees Genome Stability in the Face of DNA Strand Breaks
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Document Date: 2013-10-31 03:43:10


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File Size: 3,52 MB

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Geneva / Cruz / NVP / Sausville / Basel / Santa Cruz / /

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Wilson / Novartis Pharma AG / Astrophysics Research Corporation / Slm / Bio-Rad / Bernstein / Stephens / Elsevier Inc. / /

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FDA Phase / Product Issues / /

Facility

University of Basel / Rad53 checkpoint / TOR complex / TORC2 complex / University of Geneva / Miescher Institute / TORC1 complex / M. Hall / Mec1-Ddc2 complex / /

IndustryTerm

active site / inhibition protocol / catalytic site / putative active site / Reaction products / fluorescence imaging / cytotoxic natural product / /

MedicalCondition

ataxia telangiectasia / tumor / lack of coordination / cancer / strain / DNA damage hypersensitivity / tumour / extreme hypersensitivity / mammalian cancer / pancreatic cancer / glioblastoma / Zeocin hypersensitivity / certain cancer / /

MedicalTreatment

radiation therapy / chemotherapy / chemotherapies / radiation / /

Organization

University of Basel / University of Geneva / DNA Strand Breaks Kenji Shimada / 1 / 5 Ireos Filipuzzi / 2 / 5 Michael Stahl / 3 Stephen B. Helliwell / 2 Christian Studer / 2 Dominic Hoepfner / 2 Andrew Seeber / 1 / 4 Robbie Loewith / 3 N. Rao Movva / 2 and Susan M. Gasser1 / 4 / * 1Friedrich Miescher Institute for Biomedical Research / European Research Council / Swiss National Science Foundation / Novartis Research Foundation / /

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R. Rothstein / Nat / /

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Bishop / CHEF / Major / /

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cisplatin / hydroxyurea / Zeocin / SC / Bleomycin / HR / Impaired NHEJ / FK506 / /

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Received / /

PublishedMedium

Molecular Biology / /

Technology

radiation / X-Ray / Electrophoresis System / Antibodies / polymerization / chemotherapy / ATM / recombination / gel electrophoresis / human genome / Apoptosis / selective TORC2 inhibition protocol / /

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http /

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