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Macrolides / Biology / Biguanides / Guanidines / Chemistry / Metformin / Mammalian target of rapamycin / Sirolimus / AMP-activated protein kinase / Medicine / Protein kinases / Lymphoma


Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy
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Document Date: 2012-03-01 05:57:38

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Glostrup / St. Louis / Santa Cruz / Shanghai / Rockville / Helsinki / Palo Alto / Cologne / Cambridge / Darmstadt / Berkshire / /

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Vercesi AE / Addgene Inc. / TAAB Laboratories / Sigma-Aldrich / Miltenyi Biotech Inc. / Merck KGaA / 1 State Key Laboratory / Promega Corporation / IgG / Epitomics Inc. / Ge / US Biomax Inc. / Creative Commons / Macmillan Publishers Limited / State Key Laboratory / /

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Netherlands / United Kingdom / China / Denmark / Germany / United States / /

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Facility

Laboratory of Molecular Pathology / Shanghai Laboratory Animal Center / Hall MN / State Key Laboratory of Medical Genomics / Shanghai Institute of Hematology / Shanghai Rui Jin Hospital / /

IndustryTerm

therapy for lymphoma / cancer therapy / lymphoma therapy / lymphoma therapies / energy-sensing cytokinetic tumor suppressor / main cellular energy sensor / Diabetes Care / stock solution / treatment of lymphoma / lymphoma treatment / cellular energy status / /

MedicalCondition

ovarian cancer / papillary thyroid cancer / lymphoma cell lines / lymphoma cell apoptosis / vivo lymphoma growth / lymphoma cell growth / lymphoma cell proliferation / B- and T-cell lymphoma / mTOR-activated lymphoma / diabetic cancer / melanoma / tumor growth / energy-sensing cytokinetic tumor / mice tumor / lymphoma increases / lymphoma cell engraftment / prostate cancer / metformin-induced lymphoma cell growth inhibition / breast cancer / metformin-mediated lymphoma cell growth inhibition / murine lymphoma xenograft models / malignant lymphoma cells / leukemia / tumor / lymphoma progression / non-Hodgkin lymphomas / Cancer / tumors / lymphoma treatment / murine lymphoma models / diabetes / linked tumor / less lymphoma cell growth inhibition / T-cell lymphoma models / human lymphoma / acute myeloid leukemia / primary tumor / lymphoma cell response / non-stem cancer / diabetic prostate cancer / significantly inhibited tumor / lymphoma / lymphoma cell sensitivity / hematological malignancies / lymphoma cell growth inhibition / Wiestner A. Mantle cell lymphoma / anaplastic lymphoma kinase-positive anaplastic large cell lymphoma / In lymphoma / Fresh lymphoma cells / significantly inhibited xenograft lymphoma growth / Mice lymphoma samples / lymphoma therapy / human lymphoma cell lines / pancreatic cancer / cancers / lymphoma cases / follicular lymphoma cells / metformin-treated tumors / murine xenograft lymphoma models / Disease / human lymphoma tissue array / lymphoma growth / human lymphoma tissue using tissue array / Decreased tumor / solid tumor / lymphoma cell autophagy metformin / diffuse large B-cell lymphoma / abrogated lymphoma cell growth inhibition / lymphoma cell autophagy / lymphoma cells / Hodgkin’s lymphoma / primary lymphoma cells / murine lymphoma xenografts / remarkably blocked tumor / B-cell lymphoma / significantly diminished xenograft tumor / lymphoma cell autophagy biological process / /

MedicalTreatment

cancer therapy / bypass / chemo / adjuvant chemotherapy / chemotherapy / /

Organization

Institutional Review Board / Shanghai Rui Jin Hospital / National Natural Science Foundation of China / Shanghai Education Development Foundation / Shanghai Institute of Hematology / Shanghai Jiao Tong University School of Medicine / Shanghai Municipal Education Commission / Internal Revenue Service / Shanghai Commission of Science and Technology / Shanghai Laboratory Animal Center / Laboratory of Molecular Pathology / /

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Activation / Ann Oncol / Bing Li Xue Za Zhi / Shu Guang / Ben Sahra / Ward E. Cancer / Al Saati / /

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Cao / /

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Adenosine / /

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South Dakota / /

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Cuervo AM / /

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siRNA / stem cells / apoptosis / chemotherapy / treating cancer / suggested protocols / Genomics / antibodies / Biotechnology / Cell Signaling / /

URL

www.nature.com/cddis / http /

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