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Cell signaling / Signal transduction / AKT / Mammalian target of rapamycin / Immunosuppressants / Macrolides / Phosphoinositide 3-kinase / Sirolimus / Phosphorylation / Biology / Cell biology / Protein kinases


Akt and mTOR mediate programmed necrosis in neurons
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Ann Arbor / Dallas / Medan / Mandeville / Pittsburgh / Cambridge / San Diego / Charlestown / St. Louis / Santa Cruz / /

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IgG / Nec / Uzdensky AB / BD Transduction Laboratories / Thermo Fisher Scientific / Honda / Cantley LC / Creative Commons / GE Healthcare / Bio-Rad / 5Neuroprotection Research Laboratory / Macmillan Publishers Limited / /

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United States / China / /

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Product Issues / /

Facility

Shanghai Medical College / Massachusetts General Hospital / 2Neuroscience Center / RIP1-RIP3 complex / Huashan Hospital / Tufts University / Fudan University / /

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IndustryTerm

culture media / molecular machinery / treatment protocols / rubber policeman / chemical and genetic approaches / Chemical inhibitor / energy metabolism regulator / /

MedicalCondition

TNF-induced necrosis / acute injury / acute CNS injury / TB / JE / focal cerebral ischemia-reperfusion injury / injury / mild transient focal cerebral ischemia / middle cerebral artery occlusion / programmed necrosis / tumor / necrosis / cancer / Disease / ischemic brain injury / neuronal necrosis / photodynamic injury / retinal ischemia-reperfusion injury / mouse brain ischemia / stroke / virus-induced inflammation / brain trauma / traumatic brain injury / tumor necrosis / HT22 cells using tumor necrosis factor-a / focal cerebral ischemia / regulated necrosis / acute central nervous system injury / CNS injury / TNFa/zVAD-induced necrosis / inflammation / HT22 necrosis / /

MedicalTreatment

antibiotics / treatment protocols / /

Organization

Harvard Medical School / Administration of Akt and mTOR / National Institute of Health / Massachusetts General Hospital / Shanghai Medical College / Tufts University / Boston / National Natural Science Foundation of China / 2Neuroscience Center / zVAD administration / Department of Pediatric Critical Care Medicine / Fudan University / Shanghai / Sackler School of Graduate Biomedical Sciences / Huashan Hospital / /

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David J / Ande SR / Ann Neurol / Kenyon V / Bano Akt / Greg Cuny / Karin M. Reactive / /

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Position

Representative western blot analysis / rubber policeman / USA *Corresponding author / Kochanek PM / Marion DW et al / Representative / /

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cisplatin / penicillin / simvastatin / Sigma / propofol / Mitosox / adenosine / Jurkat / /

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Maryland / Hawaii / Massachusetts / Arkansas / /

PublishedMedium

PLoS One / /

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Planas AM / /

Technology

alpha / Neuroscience / Antibodies / siRNA / Cell Signaling / apoptosis / gene expression / treatment protocols / gel electrophoresis / /

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