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Growth factors / Peptide hormones / Gastrointestinal cancer / Gastrointestinal stromal tumor / CD117 / Imatinib / Insulin-like growth factor 1 receptor / Tyrosine kinase / Protein kinase / Biology / Medicine / Cell signaling


Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors Chi Tarn*†, Lori Rink*†, Erin Merkel*, Douglas Flieder‡, Harsh Pathak*, Daphne Koumbi§, Joseph R. Testa§
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Document Date: 2008-06-13 16:38:28


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City

Philadelphia / NVP / Chicago / /

Company

Fox Chase / Novartis / Andersson LC / Affymetrix / Qiagen / Bone Sarcoma Group / Cell Signaling Technologies / PerkinElmer / /

Country

Lebanon / /

Currency

pence / /

/

Event

FDA Phase / /

Facility

Hitchcock Medical Center / Fox Chase Cancer Center / /

IndustryTerm

detection systems / experimental model systems / steel factor / /

MedicalCondition

Genes Chromosomes Cancer / common mesenchymal tumors / Endocr Relat Cancer / gastric cancer / Wilms’ tumors / astrointestinal stromal tumors / leiomyosarcomas / mutant tumors / tumor DNA / advanced gastrointestinal stromal tumors / pancreatic adenocarcinoma xenografts / gastrointestinal stromal tumors / solid tumors / neuroendocrine gastrointestinal tumours / given tumor / several tumor / small cell lung cancer / J Cancer / D4 colon carcinoma / WT tumors / prostate cancer / epithelial ovarian cancer / serum starvation / different human cancers / breast cancer / wild-type gastrointestinal stromal tumors / pancreatic adenocarcinoma / tumor / advanced gastrointestinal stromal tumours / Leuk Lymphoma / gastrointestinal stromal tumor / breast cancers / adult gastrointestinal stromal tumors / cancer / tumors / disease / chromosome-positive acute lymphoblastic leukemia / gastrointestinal stromal tumours / hepatocellular carcinoma / pediatric gastrointestinal stromal tumors / stromal tumors / Frozen tumor / metastatic gastrointestinal stromal tumor / chronic myelogenous leukemia / Pediatr Blood Cancer / sporadic and familial gastrointestinal stromal tumors / Gastric GI stromal tumors / positive tumor / anemia / /

MedicalTreatment

rehydration / anticancer therapy / chemotherapy / surgery / drug therapies / /

NaturalFeature

Mazur MT / /

Organization

FCCC Translational Research Committee / Hitchcock Medical Center / National Academy of Sciences / American Society of Clinical Oncology / Institute for Cancer Research / GIST Cancer Research Fund / FDA / ¶Norris Cotton Cancer Center / National Institutes of Health Training Institutional National Research Service / /

Person

Yuliya Skorogabotko / Alfred G. Knudson / Jr. / Burton Eisenberg / Joseph R. Testa / Norris Cotton / Daphne Koumbi / Mazur / Chi Tarn / Erin Merkel / Andrew K. Godwin / Douglas Flieder / Tania Stutman / Clark / Samuel Litwin / Ann Oncol / Alfred Knudson / Margaret von Mehren / Chong Xu / /

Position

HB / Author / Fisher / representative / /

Product

Gleevec / IGF1R / AEW541 / MCF7 / EORTC Soft Tissue / /

ProvinceOrState

Pennsylvania / New Hampshire / /

PublishedMedium

Cancer Research / /

Technology

gene amplification / tomography / antibodies / siRNA / hybridization / genotyping / apoptosis / electroporation / gene expression / chemotherapy / SNP / genotype / gel electrophoresis / /

URL

www.pnas.org兾cgi兾doi兾10.1073兾pnas.0803383105 / www.pnas.org/cgi/content/full / /

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