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Acute phase proteins / Hepatology / Coagulation system / Plasmin / Fibrinolysis / Wound healing / Liver / Fibrinogen / Kupffer cell / Anatomy / Biology / Blood


Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver Jorge A. Bezerra*, Thomas H. Bugge†, Hector Melin-Aldana, Gregg Sabla, Keith W. Kombrinck, David P. Witte, and Jay L. Degen
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City

Roberts / Rochester / Jensen / Bradford / New York / Joseph / Washington / London / /

Company

Vistros Chemistry Systems / Rai / Johnson & Johnson / Vector Laboratories / Amersham / Russell / Yazigi N. A. / Mead / Wilson / Phoenix Pharmaceuticals / Fort Dodge Laboratories / Bio-Rad / Accra Laboratory / La Roche Ltd. / /

Country

United States / /

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Event

Product Issues / M&A / /

Facility

University of Washington / Hospital Research Foundation / University of Cincinnati / National Institute of Dental / /

Holiday

St. Joseph / /

IndustryTerm

corn oil / Animal protocols / /

MedicalCondition

acute injury / acute hepatic injury / severe liver dysfunction / toxic liver injury / acute necroinflammatory injury / genetically superimposing fibrinogen deficiency / liver cell injury / tissue injury / cirrhosis / persistent liver injury / acute CCl4-induced liver injury / residual centrilobular inflammation / liquefaction necrosis / injury / Plasminogen deficiency / acute CCl4 injury / minimal inflammation / Persistent injury / Fibrin deficiency / toxic injury / chronic liver injury / acute liver injury / persistent centrilobular injury / similar centrilobular injury / hepatic injury / CCl4 injury / centrilobular injury / combined deficiency / cellular injury / progressive microvascular thrombosis / Liver Injury / inflammation / long-standing injury / fibrosis / cellular necrosis / /

Movie

W. / /

Organization

National Institute of Health / Department of Pediatrics / National Institute of Dental and Craniofacial Research / Hospital Research Foundation / Institutional Animal Care and Use Committee of the Children / University of Cincinnati / University of Washington / Seattle / Jay L. Degen Children’s Hospital Research Foundation / /

Person

Thomas H. Bugge / David P. Witte / Nat / Van Vlaenderen / Hector Melin-Aldana / A. Emley / W. Balistreri / Keith W. Kombrinck / Jorge A. Bezerra / Van Ness / Gregg Sabla / Earl W. Davie / /

Position

investigator / /

Product

centrilobular zones / livers / proliferative response / proteolysis / mice / tissue repair / /

ProvinceOrState

New Jersey / Ohio / Maryland / New York / Washington / A. B. / /

Technology

Transplantation / DNA synthesis / genotype / /

URL

www.pnas.org / /

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