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City Oklahoma City / Baltimore / Cary / Milwaukee / / Company SAS Institute Inc. / / / Facility American College of Physicians / University of Oklahoma Health Sciences Center / University of Oklahoma / From University of Oklahoma Health Sciences Center / Blood Center of Southeastern Wisconsin / Oklahoma Blood Institute / / IndustryTerm Drug products / / MedicalCondition nocturnal leg cramps / thrombotic thrombocytopenic purpurahemolytic uremic syndrome / Schattner A. Quinine hypersensitivity simulating sepsis / DF / leg cramps / aphasia Lethargy / dysarthria / headache / diarrhea Vomiting / diarrhea Abdominal pain / chronic renal failure / coma / nausea / thrombotic thrombocytopenic purpura / thrombocytopenia / Coma Oliguria / episodic hemolytic uremic syndrome / Syncope / Drug-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome / disorder / renal disease / diarrhea / Hemolytic Uremic Syndrome / hepatitis / chest and abdominal pain / Occult quinine-induced thrombocytopenia / No No Yes Lethargy / thrombocytopenia / microangiopathic hemolytic anemia / recurrent disease / sepsis / quinine hypersensitivity / rest cramps / Quinine-induced immune thrombocytopenia / Abdominal pain / Recurrent acute hypersensitivity / thrombotic thrombocytopenic purpura-hemolytic uremic syndrome / hypertension / immune agranulocytosis / disease / diarrhea Chest pain / Laboratory Features Abdominal pain / Quinine-mediated disseminated intravascular coagulation / nocturnal leg muscle cramps / chills / Yes No Yes Yes Lethargy / No Yes Yes Yes Yes None Headache / diabetes / thrombocytopenia and microangiopathic hemolytic anemia / fever / vomiting / bloody diarrhea Abdominal pain / heart failure / No No Yes Yes Yes Recent memory loss / Death Relapse Chronic / hemoptysis Abdominal pain / Brief Communication Quinine-Associated Thrombotic Thrombocytopenic Purpura / primary malignant disease / cough / renal failure / Thrombosis / serious illness / disorientation Seizures / anemia / acute renal failure / syndrome / hemolytic-uremic syndrome / / MedicalTreatment plasma exchange / hemodialysis / dialysis / / NaturalFeature George Dale / / Organization Center of Southeastern Wisconsin / American Society of Internal Medicine / University of Oklahoma / Med Assoc. / Oklahoma Blood Institute / Oklahoma Health Sciences Center / SAS Institute / Department of Medicine / U.S. Food and Drug Administration / American College of Physicians / / Person James N. George / Long-Term Outcomes Kiarash Kojouri / Dania Yaskanin / Sara K. Vesely / Janice McFarland / Ann Intern Med / Ann Pharmacother / / Position Ness PM / Kickler TS / author / Current Author / Fisher / / Product cyclosporine / pentostatin / mitomycin / / ProvinceOrState Oklahoma / North Carolina / Georgia / / Region western Oklahoma / Southeastern Wisconsin / / Technology antibodies / transplantation / dialysis / / URL www.annals.org / / SocialTag 
Brief Communication Quinine-Associated Thrombotic Thrombocytopenic Purpura–Hemolytic Uremic Syndrome: Frequency, Clinical Features, and Long-Term Outcomes Kiarash Kojouri, MD, MPH; Sara K. Vesely, PhD; and James N. Geo