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Signal transduction / G protein coupled receptors / Laboratory techniques / Glycoproteins / Thyroid-stimulating hormone / IC50 / Thyrotropin receptor / Thyroid hormone / Hormone / Biology / Chemistry / Biochemistry


Probe Report: Identification of Potent and Selective Thyroid Stimulating Hormone Receptor Agonists
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Document Date: 2012-11-29 20:05:46

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File Size: 1,06 MB

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City

Internal / Rockville / Boston / San Diego / /

Company

Dye BD Biosciences / PerkinElmer / /

Currency

pence / /

Event

FDA Phase / /

Facility

TR-FRET cAMP / Medical Center Dr. / HTRF cAMP / National Institute of Diabetes / ATP cAMP cAMP Membrane Potential Dye Detection PDE AMP Figure / TSHR cAMP ELISA / /

IndustryTerm

assay protocol / pharmacological tool / fluorescence resonance energy transfer / research tool / therapeutic applications / /

MedicalCondition

residual tumor / Kidney Diseases / thyroid cancer / /

MedicalTreatment

AID / /

Organization

National Institute of Health / NIH Chemical Genomics Center / National Institute of Diabetes / Medical Center / /

Person

Christopher Austin / Erika Englund / Marvin GershengornA / Steve Titus / Noel Southall / Jim Inglese / Christopher Austin Assay Submitter / Susanne NeumannA / Marvin Gershengorn / Juan Marugan / Wei Zheng / /

Position

PL-HCO3 MP / /

Product

thyroglobulin / Penicillin / Chorionic Gonadotropin / adenosine / sodium iodide / TSHR / Em2 / in / F6686 / /

Technology

alpha / Chemical Genomics / Assay protocol / 33 Assay Protocol / microwave / Em2=660 nm Assay Protocol / /

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