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City Hine / Gladwin / Dallas / Noguchi / Khan / Sleeper / Baxter / Palascak / Mosso / Washington / DC / Shah / Quinn / / Company Overt / Pearson / Springer International Publishing AG / HSCT / / Country United States / / Currency USD / / Facility National Institute of Diabetes / George Washington University Medical Center / Children’s National Medical Center / University School / / IndustryTerm Stroke Prevention / care for sickle cell disease / imaging / asthma management / treatment of sickle cell disease / carrier rate / / MedicalCondition sickle-cell anemia / hypersplenism / chronic transfusions ACE / cerebral infarction HbSS / chest pain / acidosis / Sickle Cell Anemia / Acute Chest Syndrome / chronic renal failure / dysfunction / large vessel disease / thal Chronic / infectious / chronic haemolysis / leukocytosis / chronic transfusions / Albuminuria / pulmonary / Cerebrovascular accidents / Chronic kidney disease / disorder / narcotic dependence / end-stage renal disease / severe disease / infections / overt stroke / back pain / graft versus host disease / influenza / highest sickle cell trait / sepsis / wheezing / asthma / hemoglobinopathies / proteinuria / pneumonia / fat embolism / hypoventilation / hypertension / disease / respiratory failure / Cerebral infarction / malaria / iron overload / Kidney Diseases / chronic / ESRD / Streptococcus pneumoniae infections / stroke / leg ulcers / atelectasis / pulmonary hypertension / fever / Pain / chronic transfusion / bacterial infection / Sickle Cell Disease / pneumococcal infection / infection / cough / disorders / dehydration / / MedicalTreatment immunization / blood transfusion / antibiotics / Vaccination / Physical therapy / blood transfusions / mechanical ventilation / gene therapy / joint replacement / relaxation / Pain Management / breathing exercises / / Organization National Institute of Diabetes / The George Washington University Medical Center / Center for Cancer / Department of Pediatrics / Center for Cancer and Blood Disorders / British Committee / Centers for Disease Control and Prevention / National Medical Center / American Academy / FDA / Washington University / / Person Ann Trop Paediatr / Cerebral / Y. Terry Lee / Gene-Targeted Therapies / Clin Pediatr / Bethesda / Colleen Byrnes / Emily Riehm / Gene-Targeted Therapies Infants / Arch Dis Child / / Position candidate for experimental gene therapy / MP / King / Major / / Product Hydroxyurea / Penicillin / IV / / ProvinceOrState New Jersey / Alabama / Alaska / Louisiana / Connecticut / Manitoba / Montana / Massachusetts / / RadioStation Am 1987 / / Technology x-ray / polymerization / transplantation / stem cells / human genome / MRI / gene therapy / Laser / magnetic resonance imaging / http / / URL www.clinicaltrials.gov / / SocialTag 
Drugs 2012; 72 (7): [removed][removed]/$[removed]REVIEW ARTICLE Adis ª 2012 Springer International Publishing AG. All rights reserved.