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Transcription factors / Hypoxia-inducible factors / Vascular endothelial growth factor / VEGF receptors / Angiogenesis inhibitor / Retina / Angiogenesis / HIF-1 alpha IRES / Von Hippel–Lindau tumor suppressor / Biology / Angiology / Medicine


PNAS PLUS Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4 Xiaoban Xina, Murilo Rodriguesa, Mahaa Umapathia, Fabiana Kashiwabuchia, Tao Mab,c,d,
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City

MIO / Santa Cruz / Baltimore / London / /

Company

Carl Zeiss Inc. / Jackson Laboratory / BD Transduction Laboratories / Millipore / Qiagen / IPL / Dvorak HF / Chin HF / Corning / IgG / Lifespan BioSciences / GE / Vegf mRNA / Affymetrix / Charles River Laboratories / EDN1 / /

Country

United Kingdom / /

Currency

pence / /

/

Facility

National Eye Institute / Nathan Institute of Genetic Medicine / Institute of Ophthalmology / Microarray Core Facility / University College London / Wilmer Eye Institute / University of Maryland / Johns Hopkins University / /

IndustryTerm

dependent target gene products / serum starvation media / important tool / conditioned media / diverse / mg/mL solution / treatment of obesity / /

MedicalCondition

Susac’s syndrome / macular edema / osteoclast-mediated bone resorption / JE / acidosis / certain retinal diseases / arthritis / retinal diseases / distant metastasis / injury / Kaposi’s sarcoma / serum starvation / hypoxic breast cancer / tumor / diabetic retinopathy / cancer / metabolic diseases / stroke / lung metastasis / diabetes / Prevent Blindness / breast tumors / diseases / incontinentia pigmenti / diabetic macular edema / Endothelial infection / retinal vein occlusion / Infection / human hepatocellular carcinoma / ischemic retinal disease / vascular metastasis / glaucoma / human colon cancer / conventional renal cell carcinoma / human gastric cancer / human colorectal cancer / metastasis / block tumor / Müller Glial Cell Injury / retinopathy of prematurity / retinal ganglion / obesity / age-related macular degeneration / unique vascular tumor Kaposi’s sarcoma / regional lymph node metastasis / worldwide diabetes epidemic / chronic ischemia / epiretinal membrane / disease / ischemic diseases / Müller cell injury / diabetic eye disease / inner retinal cysts / retinal degeneration / retinal neovascularization / tumor metastasis / retinal edema / overnight starvation / early colorectal cancer / /

MedicalTreatment

pharmacotherapies / /

Organization

Wilmer Eye Institute / National Eye Institute / the Johns Hopkins University / Association for Research / University of Maryland / Johns Hopkins University Animal Care and Use Committee / School of Medicine / Medicine / and dGreenebaum Cancer Center / Johns Hopkins School of Medicine / Nathan Institute of Genetic Medicine / Medicine Internal Review Board / University College London / Department of Pathology / Harvard / School of Dentistry / Institute for Cell Engineering / Johns Hopkins University / Ella Owens Medical Research Foundation / Institute of Ophthalmology / Johns Hopkins University School of Medicine / Johns Hopkins School / /

Person

Imran Bhuttoa / Peter J. McDonnell / Stephen J. Ryan / Jr. / Astrid Limb / Ella Owens / Harlan Sprague / Derek S. Welsbiea / Charles G. Eberharta / Tao Mab / Morton F. Goldberg / James T. Handaa / Evan Blue / J. Ryan / Gerard Luttya / Silvia Montanerb / Elia J. Duha / Van de Wiele / Evans Blue Absorbance / Gene Array / Gregg L. Semenzae / /

/

Position

multifunctional molecular player / General / Author / Representative / VP / WB / Chairman / important mediator / Munro PM / angiogenic mediator / /

Product

Evans Blue / digoxin / Tao / DV / Intravitreal injection / penicillin / System (Dako) / RNAi / /

ProgrammingLanguage

ABC / /

ProvinceOrState

Maine / Georgia / Maryland / /

PublishedMedium

PLoS One / /

RadioStation

Mowat FM / Cleton-Jansen AM / /

TVStation

KSHV / /

Technology

Proteomics / 3-d / siRNA / DNA Chip / gene expression / alpha / antibodies / /

URL

www.pnas.org/lookup/suppl/doi / www.pnas.org/cgi/doi/10.1073/pnas.1217091110 / /

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