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Ion channels / TRPV / Hemorrhagic cystitis / Urination / Cyclophosphamide / Urothelium / Cystitis / Mechanosensation / Urinary incontinence / Medicine / Biology / Anatomy


Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis Wouter Everaertsa,b,c,1, Xiaoguang Zhend,1, Debapriya Ghosha,c, Joris Vriensa,c, Thomas Gevaertb,e,
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Document Date: 2010-10-21 13:10:05

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City

Austin / Boston / Novara / Leuven / Cambridge / /

Company

JG (2004) Management / GlaxoSmithKline / R.V. D.D. / Functional Bladder Capacity / Cox / Hydra Biosciences / Suzuki / dHydra Biosciences / /

Country

Italy / Belgium / /

Currency

pence / /

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Event

Product Issues / /

Facility

The University of Texas / Duke University / Tufts University / University Hospitals Leuven / Laboratory of Ion Channel Research / /

IndustryTerm

therapy for bladder storage disorders / treatment of bladder storage dysfunction / chemical agonists / hyposmotic solution / healthcare systems / imaging / pharmaceutical therapies / treatment of bladder dysfunction / /

MedicalCondition

cystitis-induced bladder dysfunction / overactive bladder / severe hemorrhagic cystitis / TRPV4-related diseases / bladder storage disorders / headache / urinary retention / bladder dysfunction / urge incontinence / visceral hypersensitivity / bladder storage dysfunction / multiple sclerosis / benign prostatic hyperplasia / illness / constipation / dorsal root ganglion / hearing impairment / Cyclophosphamide cystitis / clinically diverse diseases / spinal cord injury / TRPV4 cause Charcot-Marie-Tooth disease / spinal muscular atrophy / disease / cystitis / cyclophosphamide-induced hemorrhagic cystitis / bladder outlet obstruction / contraction / strong hemorrhagic cystitis / Cyclophosphamide-Induced Cystitis / neurological disease / overactive bladder syndrome / overactive bladder/urinary incontinence / allelic disorders / prostatic hyperplasia / Tooth disease / divergent hereditary diseases / contraction of the detrusor muscle / /

MusicGroup

C.M. / /

Organization

Research Council of Katholieke Universiteit Leuven Grants GOA / International Continence Society / Department of Molecular Cell Biology / University of Texas at Austin / European Union Community Council / Tufts University / Duke University / Durham / Belgian Federal Government / Laboratory of Ion Channel Research / i.p. administration / Katholieke Universiteit Leuven / Astellas European Foundation / Department of Surgery / Subsequent administration / Research Foundation / /

Person

David Kimball / Arch Pharmacol / James P. Gilbertd / Colleen R. McNamarad / Neil J. Haywardd / Sara Kerselaers / Melissa Benoit / Richard W. Aldrich / Christopher M. Fangerd / Bernd Niliusa / Thomas Gevaertb / Valeri Agueev / Timothy Strassmaierd / Rudi Vennekensa / Eda Uykald / Magdalene M. Morand / W. Liedtke / Dirk De Ridderb / Xiaoguang Zhend / Thomas Voetsa / Christine Bellon / /

Position

Cuajungco MP / WT mice Author / representative / /

Product

cyclophosphamide / Trpv4 / aging-related hearing impairment / pressure sensation / osteoclast maturation / osmotic sensation / /

ProvinceOrState

Texas / Massachusetts / /

Technology

Gene expression / PDH / genotype / /

URL

www.pnas.org/cgi/doi/10.1073/pnas.1005333107 / www.pnas.org/lookup/suppl/doi / /

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