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Macrophage / Ursolic acid / Interleukin / T helper cell / Tumor necrosis factor-alpha / STAT3 / Immunosuppressive drug / Cancer immunotherapy / Oncogene / Biology / Immune system / Cytokines


A Novel Strategy for Inducing the Antitumor Effects of Triterpenoid Compounds: Blocking the Protumoral Functions of Tumor-Associated Macrophages via STAT3 Inhibition
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City

Article / /

Company

Ge / Hp / Creative Commons / Hindawi Publishing Corporation / /

Country

United States / /

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Event

FDA Phase / /

Facility

Kumamoto University / Hp complex / /

IndustryTerm

cancer therapy / Chemical structures / /

MedicalCondition

myxoid liposarcoma / experimental gliomas / In vitro anti-breast cancer / gastric cancer / ovarian cancer / human malignant tumors / tumor cell culture supernatant / malignant tumor / M4Beu melanoma / Nature Reviews Cancer / tumor cell proliferation using tumor / several human malignant tumors / human gastric cancer / metastasis / skin blisters / glioma / HuH7 human hepatocellular carcinoma / skin cancer / intrahepatic cholangiocarcinoma / clear cell renal cell carcinoma / septic peritonitis / several tumor / Aberrant inflammation / colon cancer / U373 glioblastoma cell line / human leukaemia cells / adult T-cell leukemia/lymphoma / glioblastoma cell proliferation / sensitized tumor / renal cell carcinoma / human breast cancer / breast cancer / osteosarcoma and glioblastoma cells / pancreatic cancer / Glioblastoma / OA also directly inhibited tumor / Ovarian carcinoma / human gliomas / deleterious and inflammatory cells / leukemia / tumor / both tumor / also suppressed tumor / malignant tumors / different tumor / cervix adenocarcinoma cells / immune dysfunction / Suppression Suppression Suppression Tumor / cancer / chronic enterocolitis / tumors / disease / atherosclerosis / CA significantly suppressed lung metastasis / several inflammatory molecules / hepatocellular carcinoma / Carcinogenesis / human myxoid liposarcoma cells / inflammatory and adaptive Th1 responses / day Tumor / human cancer / murine sarcoma / tumour / osteosarcoma / lung metastasis / subcutaneous tumor / NCI-N87 human gastric cancer / Hodgkin lymphoma / tumor necrosis / gemcitabine-resistant human pancreatic cancer / decrease tumor / lung cancer / osteosarcoma cells / glioma model / mouse sarcoma / porcine reproductive and respiratory syndrome viruses / tumor cell supernatant / inflammation / murine tumor / breast and prostate cancer / developed tumor / porcine reproductive and respiratory syndrome virus / tumours / /

MedicalTreatment

anticancer therapy / cardiopulmonary bypass surgery / immunotherapy / cancer therapy / immunosuppression / anti-cancer therapy / Phytotherapy / /

Organization

Kumamoto University / CA administration / Yoshihiro Komohara Department of Cell Pathology / National Academy of Sciences / Oral administration / CA ADR / Graduate School / Faculty of Life Sciences / /

Person

Junko Nakao / Yukio Fujiwara / Kenichi Takemura / Osamu Nakamura / Yoshihiro Komohara / Kiyomi Takaishi / Hasita Horlad / Koji Ohnishi / Yui Hayashida / Emi Kiyota / Daisuke Shiraishi / Takenobu Nakagawa / /

Position

Academic Editor / /

Product

cisplatin / Cyclosporine / LM8 injection / corosolic / /

ProvinceOrState

California / /

PublishedMedium

Journal of Virology / Nature Reviews Cancer / Journal of Clinical Investigation / Journal of Agricultural and Food Chemistry / Cancer Research / Nature Reviews Immunology / Proceedings of the National Academy of Sciences / PLoS ONE / Journal of Immunology / British Journal of Pharmacology / /

Technology

Biotechnology / apoptosis / gene expression / treating cancer / /

URL

http /

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