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Non-steroidal anti-inflammatory drugs / Pharmacology / Pfizer / Sulfonamides / Isoxazoles / Rofecoxib / Celecoxib / Parecoxib / Valdecoxib / COX-2 inhibitors / Chemistry / Organic chemistry


The Need for Revision of Pre-Market Testing The Failure of Animal Tests of COX-2 Inhibitors John J. Pippin, M.D., F.A.C.C. FDA Open Public Hearing Arthritis Advisory Committee
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Document Date: 2011-03-06 12:21:14

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File Size: 633,39 KB

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City

Bordeaux / /

Company

Merck Research Laboratories / Merck and Co. Inc. / Novartis Animal Health U.S. Inc. / New England Journal / COX / Pharmacia / /

Country

France / United States / United Kingdom / /

Currency

USD / /

Event

FDA Phase / Product Issues / Product Recall / /

Facility

National Cancer Institute / /

IndustryTerm

cancer prevention / event risk products / pharmaceuticals / intensive advertising campaign / Intensive directto-consumer advertising / /

MedicalCondition

strokes / dementia / cal injury-induced atherosclerosis / arthritis / such atherosclerosis / endotoxemia / CV thrombosis / heart disease / JAMA Syndrome / toxic epidermal necrolysis / emic injury / Stevens-Johnson Syndrome / ischemic injury / heart attacks / injury / renal disease / human diseases / gastric ulcers / Spontaneous Adenomatous Polyps / mechanisms cardiac dysfunction / cancer / atherosclerosis / sudden cardiac death / pain / LPS-induced endotoxemia / heart attack / diseases / thrombosis / excess heart attacks / /

MedicalTreatment

coronary artery bypass surgery / /

Movie

On the Road / /

Organization

National Cancer Institute / National Institute of Health / FDA’s Arthritis Advisory Committee / Risk Management Advisory Committee / COX-2 association / Congress / U.S. Food and Drug Administration / FDA / Physicians Committee for Responsible Medicine / National Health Service / /

Person

Raymond Gilmartin / Marie Grif / Wayne Ray / Curt Furberg / Garret FitzGerald / C. Michael Stein / Elias Zerhouni / David Graham / Novemcuracy / Lester Crawford / Susan Paulson / Gail Cawkwell / /

Position

director for Bextra and Celebrex / worldwide medical director / researcher / prolific investigator / co-author / director / president and CEO / independent author / /

Product

depen / Lodine / Bextra / Rimadyl / Etodolac / meloxicam / COX-2 / naproxen / Mobic / Feldene / Celebrex / Vioxx / ibuprofen / Piroxicam / United States / /

PublishedMedium

the New England Journal of Medicine / /

Technology

drug metabolism / Human Genome / pharmacokinetics / recombinant DNA technology / Drug Development / /

URL

www.PCRM.org / /

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