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Microbiology / Protein methods / Viruses / Adeno-associated virus / Resolution / Capsid / Cryo-electron microscopy / X-ray crystallography / Virus-like particle / Biology / Protein structure / Diffraction


Structural Insight into the Unique Properties of Adeno-Associated Virus Serotype 9 Michael A. DiMattia,a* Hyun-Joo Nam,a* Kim Van Vliet,a Matthew Mitchell,a Antonette Bennett,a Brittney L. Gurda,a* Robert McKenna,a Norma
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Document Date: 2012-06-04 18:43:52


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City

Gainesville / Carlsbad / Richardson / La Jolla / Jolla / Topsfield / Bethesda / San Diego / /

Company

IgG / AAV9 / Data Bank / USAa / Schrödinger LLC. / Orbital Biosciences LLC / /

Country

United States / /

Currency

pence / /

/

Event

FDA Phase / /

Facility

McKnight Brain Institute / Model building / Laboratory of Structural Biology Research / University of Florida / Laboratory Medicine / College of Medicine / University of Texas / University of Pennsylvania / University of California / /

IndustryTerm

peripheral nervous systems / energy minimization / treatment of heart failure / treatment of neurodegenerative diseases / heparan sulfate binding site / mapped antigenic site / software suite / therapeutic gene delivery applications / gene therapy applications / putative aphid recognition site / model-building tools / space / /

Movie

Close-up / /

Organization

pentagon / University of California / National Institute of Health / National Science Foundation / Cornell / Department of Microbiology and Cell Science / McKnight Brain Institute / American Society for Microbiology / Division of Cell and Molecular Therapy / Department of Pediatrics / Division of Transfusion Medicine / Department of Molecular Genetics / Department of Microbiology / UNIV OF CALIF SAN DIEGO / Agouron Foundation / Department of Bioengineering / UNIV OF CALIF SAN DIEGO Department of Biochemistry and Molecular Biology / Intravenous administration / Center for Structural Biology / Powell Gene Therapy Center / University of Pennsylvania / Philadelphia / Department of Chemistry and Biochemistry / Division of Biological Sciences / Pediatrics and Powell Gene Therapy Center / Laboratory of Structural Biology Research / College of Medicine / Department of Pathology and Laboratory Medicine / University of Florida / San Diego Supercomputer Center / University of Texas at Dallas / /

Person

Byung-Ho Kang / Katherine Dedrick / Sergei Zolotukhin / Ulrich Englich / Microbiology Gene / Mark Potter / Nat / Mavis Agbandje-McKennaa / Gene Ther / George Aslanidi / Kim Van Vliet / Bill Miller / Sujata Halder / Scott Smith / Barry J. Byrne / Irina Kriksunov / Mavis Agbandje-McKenna / Powell Gene / Yoshihisa Sakai / Karen Kelley / Mike Cook / Timothy S. Baker / Nicholas Muzyczka / Marian D. Szebenyi / David J. Schuller / Hyun-Joo Nam / Robert Ng / Robert McKenna / /

Position

VP / VP residues / N-terminal VP / homology model built / VP regions / VP structure / Fisher / /

Product

Apollo / AAV1 / /

ProvinceOrState

Texas / Maryland / New Mexico / Pennsylvania / Delaware / Florida / California / /

PublishedMedium

Journal of Virology / Molecular Biology / /

SportsEvent

ufl / /

Technology

X-ray / relational database / antibodies / API / directed mutagenesis / DNA shuffling / recombinant AAV technology / Gene Therapy / Crystallization / gene delivery / http / /

URL

http /

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