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Cell biology / Protein kinases / Proteins / Scaffold protein / Extracellular signal-regulated kinases / Allosteric regulation / Ultrasensitivity / Mitogen-activated protein kinase / MAP kinase kinase kinase / Biology / Signal transduction / Cell signaling


Exploitation of Latent Allostery Enables the Evolution of New Modes of MAP Kinase Regulation Scott M. Coyle,1,2 Jonathan Flores,1 and Wendell A. Lim1,3,* 1Howard Hughes Medical Institute, Department of Cellular and Molec
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Document Date: 2014-12-24 04:42:34


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File Size: 2,70 MB

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City

San Francisco / /

Company

Fus3 MAPK / Elsevier Inc. / /

Country

United States / /

Facility

Ste5 scaffold / Fus3 complex / Hughes Medical Institute / AND Ste5 scaffold / N terminal / University of California / This scaffold / /

IndustryTerm

active site / multicomponent regulatory systems / molecular networks / natural systems / kinase network / conformational energy landscape / model systems / to allosteric systems / /

Organization

Department of Cellular and Molecular Pharmacology / University of California / San Francisco / San Francisco / MAP Kinase Regulation Scott M. Coyle / 1 / 2 Jonathan Flores / 1 and Wendell A. Lim1 / 3 / * 1Howard Hughes Medical Institute / USA 3UCSF Center for Systems and Synthetic Biology / /

Person

Scott M. Coyle / Taylor Ringia / /

Product

Ste5 / /

ProvinceOrState

California / /

Technology

protein engineering / cell signaling / cmp / /

URL

http /

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