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Molecular biology / Immune system / Applied genetics / Viral vector / Complement system / Coagulation / Gene therapy / Antibody / Vector / Biology / Gene delivery / Coagulation system


Advancing Regulatory Science FDA discovery that Ad5 vector uses coagulation factor X to block complement proteins has major implications for gene therapy Common wisdom has held that the gene transfer vector adenovirus 5
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Facility

Meiji Pharmaceutical University / /

MedicalTreatment

gene therapy / /

Organization

Department of Biochemistry / FDA / Division of Cellular / Center for Biologics Evaluation and Research / US Food and Drug Administration / Meiji Pharmaceutical University / Tokyo / office of Cellular / /

Person

Tissue Therapies / Jeffrey S. Smith / Jie Tian / Gene Therapies / Andrew P. Byrnes / Gina M. Conenello / /

Position

Corresponding author / /

PublishedMedium

Nature Medicine / /

Technology

gene therapy / antibodies / /

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