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Ribozymes / RNA splicing / Chemical kinetics / Biomolecules / Catalysis / Hairpin ribozyme / Enzyme / Förster resonance energy transfer / Reaction rate / Chemistry / Biology / Genetics


Dissecting the multistep reaction pathway of an RNA enzyme by single-molecule kinetic ‘‘fingerprinting’’ Shixin Liu*, Gregory Bokinsky*, Nils G. Walter†, and Xiaowei Zhuang*‡§¶ Departments of *Chemistry and
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Document Date: 2007-08-08 18:31:16


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File Size: 1,32 MB

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City

Cambridge / Diego / San Diego / New York / New Haven / /

Company

LG / HP / Thomson / Mckinney SA / /

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United States / /

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Facility

Although stable / W. M. Keck Foundation Biotechnology Resource Laboratory / §Howard Hughes Medical Institute / Massachusetts Institute of Technology / University of Michigan / Yale University / Harvard University / /

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active site / cleavage site / fluorescence resonance energy transfer / interaction network / reagents/analytic tools / cleavage products / chemical reaction step / approximate solution / cleavage product / chemical kinetics / chemical reaction intermediates / analysis software / /

Organization

G8 / University of Michigan / Ann Arbor / Harvard University / National Science Foundation / W. M. Keck Foundation Biotechnology Resource Laboratory / Massachusetts Institute of Technology / National Academy of Sciences / Howard Hughes Medical Institute / Yale University / ‡Physics / and §Howard Hughes Medical Institute / Department of Chemistry / /

Person

Nils G. Walter / Elio Abbondanzieri / Gregory Bokinsky / /

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Investigator / Author / Representative / /

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DC / /

ProvinceOrState

UC / New York / Massachusetts / Michigan / /

URL

http /

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