Packard Center / University of California San Francisco/Howard Hughes Medical Institute / terminal His-tagged FUS / The University of Pennsylvania School / terminal GST-tag / terminus of FUS / terminal NLS / /
IndustryTerm
proteostasis network / galactose-containing media / raffinose media / bioinformatic algorithm / galactose media / genetic and chemical modifiers / /
MedicalCondition
Lou Gehrig’s disease / neurodegenerative disease / familial disease / Huntington’s disease / amyotrophic lateral sclerosis / protein misfolding disorders / fatal human neurodegenerative disease / spinocerebellar ataxia type / human myxoid liposarcomas / rapidly progressing motor neuron wasting disorder / human neurodegenerative disease / frontotemporal lobar degeneration / numerous neurodegenerative disorders / basic disease / paralysis / Alzheimer’s disease / several human neurodegenerative diseases / human neurodegenerative diseases / liposarcoma / predominant disease / disease / complex human neurodegenerative diseases / basophilic inclusion body disease / motor neuron dysfunction / lateral sclerosis / ALS disease / sarcoma / Parkinson’s disease / familial and sporadic disease / heat shock / human disease / disorders / spinocerebellar ataxia / /
Organization
National Institute of Health / University of California San Francisco/Howard Hughes Medical Institute / Packard Center for ALS Research / The University of Pennsylvania School of Medicine / Department of Biochemistry and Biophysics / University of Pennsylvania Diabetes and Endocrinology Research Center / Department of Cell and Developmental Biology / /
Person
Lou Gehrig / /
Position
original author / model aspects / Author / Academic Editor / Hart MP / Director / representative / /
Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS Zhihui Sun1., Zamia Diaz2., Xiaodong Fang1, Michael P. Hart1, Alessandra Chesi1, James Shorter2*, Aaron D. Gitl