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Immunology / Oncology / Immune system / PD-1 / Immunotherapy / CpG Oligodeoxynucleotide / CD25 / PD-L1 / TLR9 / Medicine / Biology / T cells


Immune modulating effects of cyclophosphamide and treatment with tumor lysate/CpG synergize to eliminate murine neuroblastoma
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City

Waukesha / R01 / Rizzuto / IFN / Auburn / San Carlos / Gilman / Cleveland / Diego / Buhtoiarova / London / San Diego / Milwaukee / Waltham / /

Company

Jackson Laboratory / Tree Star Inc / Pearson / Cox / CTL Analyzers LLC / Creative Commons / El-Naggar SA / BD Biosciences / PerkinElmer / The International Neuroblastoma Risk Group / /

Country

United States / /

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Event

FDA Phase / /

Facility

Children’s Hospital of Wisconsin / laboratory of Dr / Biomedical Resource Center / Medical College of Wisconsin Institutional Animal Care / Medical College of Wisconsin / Laboratory Animal Care / National Cancer Institute / Children’s Research Institute / University of California / /

IndustryTerm

inoculation site / treatment site / biophotonic imaging showing loss / imaging / care protocols / tumor site / treatment of refractory disease / antigen processing / /

MedicalCondition

refractory disease / treatment containing tumor / pediatric cancer / lymphoma / multiple myeloma / neuroblastoma standard / multiple myeloma model / Neuroblastoma / infectious / AgN2a tumor / palpable tumor / localized neuroblastoma / lymphopenia / mice tumor / murine neuroblastoma / high-risk disseminated disease / Subcutaneous neuroblastoma / tumor / Cancer / tumors / subcutaneous tumors / Days post tumor / cell-based tumor / established neuroblastoma / neuroblastoma regresses / allogeneic tumor / Lymphodepletion Background Neuroblastoma / PD-L1-negative murine neuroblastoma / murine tumor / established tumor / live tumor / rhabdomyosarcoma / /

MedicalTreatment

immunization / adoptive transfer / chemotherapy / ImmunoTherapy / treatment protocol / /

Organization

Medical College of Wisconsin / Milwaukee / National Institute of Health / antiPD-1 administration / Department of Pediatrics / Cy administration / Division of Hematology/Oncology/Transplant / University of California / San Francisco / /

Person

William A. Weiss / Michael Dwinell / Jon Wigginton / /

Position

Prime Minister / MP / WB / author / /

Product

cyclophosphamide / AgN2a / antiPD-1 / T / /

ProgrammingLanguage

DC / /

ProvinceOrState

Wisconsin / Alabama / Alaska / Tennessee / California / Georgia / /

Technology

Antibodies / transplantation / apoptosis / chemotherapy / care protocols / delivered following hematopoietic stem cell transplantation / /

URL

http /

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