| Document Date: 2008-06-09 07:55:04
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City Norwalk / Baltimore / / Facility National Cancer Institute / / IndustryTerm toxic carrier material cremophor / treatment of CNS leukemia / energy-dependent pump / / MedicalCondition neoplasms / ovarian cancers / superficial bladder cancers / gonadal testicular dysfunction / ovarian cancer / multiple myeloma / retinoblastoma / wk Bone marrow depression / convulsion / ischemic heart disease / stomatitis / neuroblastoma / abnormal healing Lomustine Brain tumors / chronic therapy / pulmonary fibrosis / melanoma / choriocarcinoma / small-cell lung cancer / pulmonary and renal damage / lesions Stable disease / liver cirrhosis / flulike syndrome / diarrhea / squamous cell cancer / response Tumors / carcinoid / brain tumors / Gliadel wafers Glioblastoma / combination chemotherapy Delayed bone marrow depression / nerve root irritation / residual tumor / leukemia / tumor / pulmonary infiltrates / Measurable disease / cancer / tumors / NSCLC / wk Delayed bone marrow depression / thromboembolism / osteosarcoma / metastatic and primary tumors / lymphomas / fever / tumor lysis syndrome / lethargy / acute lymphoblastic leukemia / lymphosarcoma / polycythemia vera / sarcoma / vomiting / mg/kg Bone marrow depression / thrombophlebitis gynecomastia / chronic myelogenous leukemia / osteoporosis / stable disease / CNS leukemia / PO Bone marrow depression / refractory solid tumors / depression / rash / hemorrhagic cystitis / refractory leukemia / cervical cancers / lymphosarcoma / chronic myelomacrocytic leukemia / local irritation / lymphoblastic lymphoma / lymphoma / mesna Bone marrow depression / headache / CNS depression / colorectal cancer / erythema Fludarabine CLL / Hodgkin’s disease / chronic lymphocytic leukemia / myelodysplastic syndromes / local phlebitis / solid tumors / facial flushing / nausea / CANCER MANAGEMENT / alopecia / peripheral neuropathy / heterogeneous tumor / Germ-cell testicular cancer / consecutive days Bone marrow depression / metastatic breast cancer / poorly soluble cancer / gonadal dysfunction Melphalan Multiple myeloma / SIADH / hepatoma / renal cell carcinoma / aplastic anemia / infections / mycosis fungoides / skin hyperpigmentation Carmustine Brain tumor / weeks Progressive disease / hepatic insufficiency / lung cancers / GI carcinomas / gynecomastia / bronchogenic carcinoma / L Bone marrow depression / gonadal dysfunction / breast cancers / disease / neuroblastoma Melanoma / acute leukemia / residual cancer / hematologic malignancies / stomatitis Cladribine Hairy-cell leukemia / drug-sensitive cancers / mucositis / Bone marrow depression / pain / small tumor / myelogenous leukemia / lung cancer / gestational trophoblastic tumors / mg/kg/d Bone marrow depression / regimen Nausea / usesa Dosages Toxicitiesb Carboplatin Ovarian cancer / bladder cancers / carcinomas / renal cell cancer / soft-tissue sarcomas / severe skin necrosis / CNS toxicity Dacarbazine Malignant melanoma / paresthesias / syndrome / / MedicalTreatment radiotherapy / surgery / immunosuppression / drug carriers / remission induction / adjuvant chemotherapy / combination chemotherapy / chemotherapy / / MusicGroup Nausea / / Organization World Health Organization / FDA / National Cancer Institute / / Person Ray Page / Methotrexate Breast / DO / Chris Takimoto / / Position notable mediator / Dorr RT / head / / Product Carboplatin / Cisplatin / Hydroxyurea / Oncovin / Cytarabine / Gliadel / Thioguanine / Doxil / allopurinol / Etoposide / Paclitaxel / Floxuridine / Prednisone / mesna / Abelcet / Cladribine / Cyclophosphamide / Ifosfamide / Mercaptopurine / DepoCyt / Pentostatin / Thiotepa / sterile water / amphotericin B / DaunoXome / Fluorouracil / Adenosine / Taxol / Mitoxantrone / Dacarbazine / / ProvinceOrState Connecticut / Maryland / / SportsEvent NHL / NHL 50 / / Technology stem cells / drug delivery / gene expression / chemotherapy / transplantation / pharmacokinetics / /
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CHAPTER 3 Principles of chemotherapy Ray Page, DO, PhD, and Chris Takimoto, MD, PhD