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CLINICAL REPORT Role of Thiopurine Metabolite Testing and Thiopurine Methyltransferase Determination in Pediatric IBD 
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Document Date: 2014-06-17 13:40:18


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Hindorf / Dallas / Boston / New York / Iowa City / Philadelphia / /

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Gilissen LP / Fraser AG / Hande SA / Proc Natl Acad Sci U S A / Grossman AB / Wilson / Ford / CBC / Renault / Holme SA / /

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Benin / United States / United Kingdom / /

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Product Issues / /

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Children’s Medical Center of New York / University of Iowa / American Gastroenterological AssociationAmerican Gastroenterological Association Institute / Medical Center of Dallas / jjMassGeneral Hospital / University School / /

IndustryTerm

therapies for inflammatory bowel disease / treatment of leukemia / therapy for Crohn’s disease / therapy for treatment of inflammatory bowel disease / treatment of inflammatory bowel disease / therapy for immunomodulation in Crohn’s disease / Treatment of Crohn’s disease / therapy of inflammatory bowel disease / /

MedicalCondition

et al. Thiopurine S-methyltransferase deficiency / infectious complication / IBD / S-methyltransferase deficient Crohn’s disease / cytomegalovirus infection / inflammatory bowel disease / Lymphoma / alternative disease / postoperative Crohn’s disease / leukopenia / Crohn disease / primary Epstein-Barr virus infection / inflammatory gene expression / thrombocytopenia / ileocolonic disease / significant leukopenia / colitis / inflammatory bowel diseases / hemophagocytic lymphohistiocytosis / chronic inflammation / lymphopenia / hypersensitivity / coronary heart disease / TPMT deficiency / bowel disease / J Crohns Colitis / hepatosplenic T-cell lymphoma / inflammatory bowel diseases receiving azathioprine / infections / active and quiescent disease / sepsis / erythrocyte aplasia / leukemia / Cytomegalovirus (CMV) infection / inflammatory bowel disease-what / uremia / Opportunistic infections / steroid-treated Crohn’s disease / disease / active Crohn’s disease / neutropenia / Crohn’s disease / both Crohn disease / fever / ulcerative colitis / active disease / early liver failure / diseases / pancreatitis / pediatric inflammatory bowel disease / non-Hodgkin lymphoma / infection / deficiency / IBD whose disease / inflammation / rash / T-cell lymphoma / EBV infections / inflammatory / pancytopenia / /

MedicalTreatment

blood transfusion / blood transfusions / induction of remission / immunosuppression / bypass / immunosuppressive therapy / /

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Abreu MT / Osterman MT / /

Organization

American Gastroenterological AssociationAmerican Gastroenterological Association Institute / Harvard Medical School / Food and Drug Administration / Committee on Inflammatory Bowel Disease / Association of Crohn / North American Society for Pediatric Gastroenterology / zChildren’s Medical Center of Dallas / North American Society for Pediatric Gastroenterology / Hepatology / and Nutrition / yCohen Children’s Medical Center of New York / NASPGHAN Committee on Inflammatory Bowel Disease ABSTRACT Thiopurines / Mount Sinai School of Medicine / ôDrexel University School of Medicine / European Society for Pediatric Gastroenterology / Hepatology / and Nutrition / University of Iowa / jjMassGeneral Hospital for Children / /

Person

Keith Benkov / Ann Clin Biochem / Riad Rahhal / /

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Prime Minister / Walker / Krumholz MP / Bishop / Irving PM / et al / Sparrow MP / /

Product

trimethoprim / SC / mesalamine / cyclosporine / Sulfasalazine / thioguanine / mercaptopurine / allopurinol / prednisolone / metronidazole / Franklin CL / prednisone / captopril / azathioprine / sulfamethoxazole / thiopurine S-methyltransferase allelic variants / Crohn’s disease patients / /

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Oregon / New York / Pennsylvania / Iowa / /

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Marinaki AM / /

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genomics / genotyping / apoptosis / pharmacogenetics / gene expression / genotype / /

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www.jpgn.org / /

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