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City Fortaleza / Lima / / Company DNA / Proc Natl Acad Sci U S A / MEDLINE / performed using MEDLINE / ABC / / Country Anguilla / United States / Brazil / Columbia / / / Event FDA Phase / Product Issues / / Facility Federal University of Ceara´ / Golgi complex / Missouri University / / IndustryTerm food preferences / food odor / pharmacological tool / intact microtubular network / food preference / food / metal co-factor ions / pharmacological tools / water transport systems / food intake preference / adenylyl cyclase enzymatic systems / food intake / ionic transport systems / aqueous media / potassium transportation / / MedicalCondition watery diarrhea / diarrheal diseases / inflammatory bowel disease / endemic enteric diseases / both endemic and epidemic cholera / headache / acidosis / colorectal cancer / daily worst abdominal pain / brain disorders / metastasis / esophagitis / Enteric infections / main agent promoting traveler’s diarrhea / nausea / colorectal cancers / enteric bacterial infection / osmotic diarrhea / colitis / clinical cholera / hyperactivity disorder / chronic constipation / obesity / diarrhea / enteropathy / enteric infection / ETEC infection / ETEC infections / cystic fibrosis / cholera toxin / constipation / asthma / malnutrition / abdominal pain / tumor / congestive heart failure / ADHD / hypertension / schizophrenia / disease / salt-sensitive hypertension / functional gastrointestinal disorders / erectile dysfunction / hyperactive disorder / cystic fibrosis transmembrane regulator / fever / Secretory diarrhea / hyperphagia and subsequent obesity / metabolic syndrome / vomiting / chronic diarrhea / Parkinson’s disease / diseases / tumor metastasis / cholera / symptomatic infection / high blood pressure / endogenous cholera / inflammation / irritable bowel syndrome / ETEC strain infections / hypokalemia / chronic ingestion / human disease / meconium ileus / dehydration / / MedicalTreatment relaxation / / Organization Federal University of Ceara´ / World Health Organization / Instituto de Biomedicina / Lima AA / Missouri University / European Committee for Medicinal Products for Human Use / US Food and Drug Administration / General Services Administration / Instituto de Cieˆncias Biome´dicas / Universidade Federal do Ceara / / Person Rodolfo Teo / Leonard Forte / / Position mediator / Professor / reporter / / Product Linaclotide / water / / ProvinceOrState Connecticut / / PublishedMedium Brazilian Journal of Medical and Biological Research / / Technology Cloning / apoptosis / spectroscopy / pharmacodynamics / drug development / / URL http / SocialTag