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Enterobacteria / Microbiology / Peptides / Escherichia coli / Heat-stable enterotoxin / Guanylate cyclase 2C / Enterotoxigenic Escherichia coli / Guanylate cyclase / Guanylin / Bacteria / Biology / Protein domains


From Escherichia coli heat-stable enterotoxin to mammalian endogenous guanylin hormones
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City

Fortaleza / Lima / /

Company

DNA / Proc Natl Acad Sci U S A / MEDLINE / performed using MEDLINE / ABC / /

Country

Anguilla / United States / Brazil / Columbia / /

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Event

FDA Phase / Product Issues / /

Facility

Federal University of Ceara´ / Golgi complex / Missouri University / /

IndustryTerm

food preferences / food odor / pharmacological tool / intact microtubular network / food preference / food / metal co-factor ions / pharmacological tools / water transport systems / food intake preference / adenylyl cyclase enzymatic systems / food intake / ionic transport systems / aqueous media / potassium transportation / /

MedicalCondition

watery diarrhea / diarrheal diseases / inflammatory bowel disease / endemic enteric diseases / both endemic and epidemic cholera / headache / acidosis / colorectal cancer / daily worst abdominal pain / brain disorders / metastasis / esophagitis / Enteric infections / main agent promoting traveler’s diarrhea / nausea / colorectal cancers / enteric bacterial infection / osmotic diarrhea / colitis / clinical cholera / hyperactivity disorder / chronic constipation / obesity / diarrhea / enteropathy / enteric infection / ETEC infection / ETEC infections / cystic fibrosis / cholera toxin / constipation / asthma / malnutrition / abdominal pain / tumor / congestive heart failure / ADHD / hypertension / schizophrenia / disease / salt-sensitive hypertension / functional gastrointestinal disorders / erectile dysfunction / hyperactive disorder / cystic fibrosis transmembrane regulator / fever / Secretory diarrhea / hyperphagia and subsequent obesity / metabolic syndrome / vomiting / chronic diarrhea / Parkinson’s disease / diseases / tumor metastasis / cholera / symptomatic infection / high blood pressure / endogenous cholera / inflammation / irritable bowel syndrome / ETEC strain infections / hypokalemia / chronic ingestion / human disease / meconium ileus / dehydration / /

MedicalTreatment

relaxation / /

Organization

Federal University of Ceara´ / World Health Organization / Instituto de Biomedicina / Lima AA / Missouri University / European Committee for Medicinal Products for Human Use / US Food and Drug Administration / General Services Administration / Instituto de Cieˆncias Biome´dicas / Universidade Federal do Ceara / /

Person

Rodolfo Teo / Leonard Forte / /

Position

mediator / Professor / reporter / /

Product

Linaclotide / water / /

ProvinceOrState

Connecticut / /

PublishedMedium

Brazilian Journal of Medical and Biological Research / /

Technology

Cloning / apoptosis / spectroscopy / pharmacodynamics / drug development / /

URL

http /

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