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Hypomethylating agent
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#	Item
1	July 8, 2013 Astex Pharmaceuticals Announces IND Candidate: ASTX727 a Potential Best-in-Class Oral Hypomethylator Investigational New Drug (IND) Application and Data Presentations Planned for the Fourth Quarter DUBLIN, Add to Reading List Source URL: astx.com Language: English Clinical research Pharmaceutical industry Food and Drug Administration Astex Eisai Decitabine Hypomethylating agent Clinical trial Drug discovery Pharmaceutical sciences Pharmacology Medicine
2	Comparison of the Efficacy and Safety of 5-day and 10day schedules of SGI-110, a novel subcutaneous (SC) hypomethylating agent (HMA), in the treatment of relapsed/refractory Acute Myeloid Leukemia (r/r AML) Gail J. Roboz Add to Reading List Source URL: astx.com Language: English Acute myeloid leukemia Myeloid leukemia MG Cars Decitabine Hypomethylating agent Oncology Medicine Acute leukemia
3	Abst. No. Outcomes of Intermediate or High Risk Myelodysplastic Syndromes (MDS) Patients Post Azacitidine and/or Decitabine Treatment Failures with SGI-110, a Novel Second Generation Hypomethylating Agent (HMA) Add to Reading List Source URL: astx.com Language: English Triazines Orphan drugs Azacitidine lactams Myelodysplastic syndrome Decitabine Hypomethylating agent Lenalidomide Acute myeloid leukemia Medicine Oncology Nucleosides
4	SGI-110, a novel second generation DNA hypomethylating agent, enhances sorafenib activity and alters the methylation signature of HCC cell lines No[removed]Simone Jueliger1, John Lyons1, Mohammad Azab2 and Pietro Taverna2 Add to Reading List Source URL: astx.com Language: English Epigenetics Hepatology Hepatocellular carcinoma Sorafenib Hep G2 DNA methylation Methylation Liver cancer Hypomethylating agent Biology Chemistry Genetics
5	DNA demethylation activity over time and safety of 3 different dose-escalation regimens of SGI-110, a novel subcutaneous (SQ) hypomethylating agent (HMA), in the treatment of relapsed/refractory patients with MDS and AML Add to Reading List Source URL: astx.com Language: English Pharmacology Azacitidine lactams Chemistry Decitabine Hypomethylating agent Nucleosides Triazines Medicine
6	Results From the Dose Escalation Phase of a Randomized Phase 1–2 First-in-Human (FIH) Study of SGI-110, a Novel Low Volume Stable Subcutaneous (SQ) Second Generation Hypomethylating Agent (HMA) in Patients with Relapse Add to Reading List Source URL: astx.com Language: English - Date: 2013-05-20 15:28:50 Triazines Epigenetics Biology Acute leukemia Myeloid leukemia Acute myeloid leukemia DNA methyltransferase Azacitidine Decitabine Oncology Medicine Nucleosides
7	Study of the correlation of baseline biomarkers and DNA demethylation to clinical responses in a phase 1/2, randomized study of SGI-110, a novel subcutaneous hypomethylating agent in the treatment of relapsed/refractory Add to Reading List Source URL: astx.com Language: English Medicine Epigenetics Biology Acute leukemia Myeloid leukemia Azacitidine Acute myeloid leukemia Hypomethylating agent Decitabine Oncology Nucleosides Triazines
8	No[removed]SGI-110, a Novel Subcutaneous (SQ) Second Generation DNA Hypomethylating Agent Achieves Improved Pharmacodynamics (PD), Safety and Pharmacokinetics (PK) in comparison to IV Decitabine (DAC) in a non-human primat Add to Reading List Source URL: astx.com Language: English - Date: 2012-12-13 18:06:00 DNA DNA methylation Epigenetics
9	ABST # A190 In Vivo Activity of SGI-110, a Novel Hypomethylating Agent for Treatment in Hematology and Solid Malignancies Jason Scholl, David Vollmer, Jared Bearss, Carissa Jones, Virgil McCarthy, Paul Severson, Sanjeev Add to Reading List Source URL: astx.com Language: English - Date: 2012-12-13 18:06:00 DNA DNA methylation Epigenetics Myelodysplastic syndrome Hypomethylating agent Decitabine Biology Medicine Nucleosides Triazines
10	1442 Determinants of Demethylation and Clinical Response In AML Patients Treated With SGI-110, a Novel Subcutaneous (SQ) Hypomethylating Agent (HMA) In a Phase 1 Study Woonbok Chung, PhD1, Pietro Taverna, PhD2, John F L Add to Reading List Source URL: astx.com Language: English P53 Programmed cell death Proteins Biology Cell biology Apoptosis

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