4277 The small GTPase Rap1 regulates intracellular ROS generation in RPE Haibo Wang1, Erika S Wittchen2, Dallas Shi3, Dean Y Li3, M. Elizabeth Hartnett1 1Dept of Ophthalmology, John A. Moran Eye Center, 3Departments of

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• RAP1GAP
• Ras subfamily
• Retinal pigment epithelium
• Macular degeneration
• Oxidase
• Medicine
• Biology
• Rap1
• NADPH oxidase