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Epigenetics / DNA / Molecular genetics / Molecular biology / Molecular neuroscience / DNA demethylation / Methylation / DNA methylation / MECP2 / Biology / Genetics / Chemistry


Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation E. Dong, M. Nelson, D. R. Grayson, E. Costa*, and A. Guidotti
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Document Date: 2008-09-06 09:04:58


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City

Berlin / Indianapolis / Chicago / /

Company

BP / Lilly / Amersham / Qiagen / Sandoz Pharmaceuticals / /

Country

United States / Canada / /

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Event

Product Issues / Product Recall / /

Facility

A. Guidotti Psychiatric Institute / Arch Gen Psychiatry / University of Illinois / DNA complex / University of Massachusetts / McGill University / National Institute of Mental Health Grants MH071667 / /

IndustryTerm

reagents/analytic tools / treatment of SZ and BP disorders / BP disorder treatment / treatment of SZ and BP disorder / /

MedicalCondition

mixed-lineage leukemia / Prefrontal dysfunction / dysfunction / both schizophrenia / BP disorder / disorder / MS / chronic schizophrenia / Cortical GABAergic dysfunction / treatment-resistant schizophrenia / cancer / schizophrenia / bipolar disorders / chronic coadministration / GABAergic dysfunction / schizophrenia receiving olanzapine / bipolar disorder / /

Organization

Department of Psychiatry / Association of Antipsychotics / National Academy of Sciences / University of Massachusetts / Worcester / Methods Animals and Drug Administration / M. Nelson / D. R. Grayson / E. Costa* / and A. Guidotti Psychiatric Institute / University of Illinois / Department of Pharmacology and Therapeutics / Institute of Mental Health Grants MH071667 / McGill University / Montreal / /

Person

M. Szyf / S. Akbarian / Dong et al. Clozapine / /

Position

Ruzicka WB / altered nuclear epigenetic function operative / messenger / operative / DNA demethylase operative / reporter / /

Product

haloperidol / divalproex sodium / Sigma / MET injection / risperidone / divalproex / MET / olanzapine / Clozapine / acetic acid / days MET / /

ProvinceOrState

Illinois / Massachusetts / /

RadioStation

Benes FM / /

Technology

NEUROSCIENCE / 5-methyl CpG ChIP / antibodies / Cell Signaling / DNA binding / acetyl H-3 ChIP / laser / gene expression / gel electrophoresis / /

URL

www.pnas.org͞cgi͞doi͞10.1073͞pnas.0805493105 / www.pnas.org/cgi/content/full / /

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